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ABC843 Anti-GITRL Antibody

Detect GITRL using this Anti-GITRL Antibody validated for use in western blotting & ICC.

Anti-GITRL Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TNFSF18, AITRL, GITRL, TL6 UniProt Number: Q9UNG2
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ABC843
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC843
      DescriptionAnti-GITRL Antibody
      Alternate Names
      • Tumor necrosis factor ligand superfamily member 18
      • Activation-inducible TNF-related ligand
      • AITRL
      • Glucocorticoid-induced TNF-related ligand
      • hGITRL
      Background InformationTumor necrosis factor ligand superfamily member 18, also known as Activation-inducible TNF-related ligand (AITRL) or Glucocorticoid-induced TNF-related ligand (hGITRL) and encoded by the gene name TNFSF18 or AITRL or GITRL or TL6, regulates numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect GITRL using this Anti-GITRL Antibody validated for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 10 μg/mL from a representative lot detected GITRL in THP-1 cells.
      Biological Information
      ImmunogenKLH-conjugated recombinant human GITRL ligand.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • TNFSF18
      • AITRL
      • GITRL
      • TL6
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~26 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in recombinant GITRL protein.

      Western Blotting Analysis: 1 μg/mL of this antibody was detected in recombinant GITRL protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC843 04053252943942