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AB15014 Anti-Glycine Receptor α3 subunit Antibody

AB15014
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIHC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15014
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glycine Receptor α3 subunit Antibody
      Alternate Names
      • glycine receptor alpha 3 subunit
      • glycine receptor, alpha 3
      • glycine receptor
      • alpha-3 polypeptide, ligand gated ion channel
      Background InformationGlycine receptor α3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family. Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals. The Glycine receptor is a neurotransmitter ligand-gated ion channel. GLRA3 is a pentamer that is composed of ligand binding alpha and structural beta subunits. When glycine binds to the receptor, chloride conductance increases which produces hyperpolarization. It is expressed in the hippocampus, olfactory bulb, and cerebellum. GLRA3 may be involved in human and murine neurological disorders.
      References
      Product Information
      FormatPurified
      Control
      • Fetal human brain tissue lysate
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: 1:100-500 dilution from a previous lot detected Glycine Receptor α3 subunit in mouse spinal cord and mouse eye tissue.
      Biological Information
      ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues surrounding the C-terminus of human Glycine Receptor α3 subunit.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Glycine Receptor α3 subunit.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with human and mouse. Rat (92%) homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GLRA3
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O75311 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
      SIZE: 464 amino acids; 53800 Da
      SUBUNIT: Pentamer composed of alpha and beta subunits (By similarity).
      SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely distributed throughout the central nervous system.
      DOMAIN: SwissProt: O75311 The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics.
      SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
      MISCELLANEOUS: The alpha subunit binds strychnine.
      Molecular WeightApprox. 48 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Glycine Receptor α3 subunit Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Glycine Receptor α3 subunit Antibody Certificates of Analysis

      TitleLot Number
      Anti-Glycine Receptor #945;3 subunit - 1987458 1987458
      Anti-Glycine Receptor 3 subunit -
      Anti-Glycine Receptor 3 subunit - 2020860 2020860
      Anti-Glycine Receptor 3 subunit - NRG1635488 NRG1635488
      Anti-Glycine Receptor a3 subunit - 2274270 2274270
      Anti-Glycine Receptor a3 subunit Polyclonal Antibody 2901551
      Anti-Glycine Receptor alpha3 subunit - LV1816408 LV1816408
      Anti-Glycine Receptor α3 subunit 3170243
      Anti-Glycine Receptor α3 subunit - 2491204 2491204
      Anti-Glycine Receptor α3 subunit - 3698133 3698133

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies