Millipore Sigma Vibrant Logo

MABN291 Anti-IMPDH1 Antibody, clone 4F9.1

Anti-IMPDH1 Antibody, clone 4F9.1 is a highly specific mouse monoclonal antibody, that targets Inosine-5'-monophosphate dehydrogenase 1 & has been tested in western blotting & IHC.

Anti-IMPDH1 Antibody, clone 4F9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: IMPDH1, IMPD1 UniProt Number: P20839
View Products on Sigmaaldrich.com
MABN291
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN291
      DescriptionAnti-IMPDH1 Antibody, clone 4F9.1
      Alternate Names
      • Inosine-5'-monophosphate dehydrogenase 1
      • IMP dehydrogenase 1
      • IMPD 1
      • IMPDH 1
      • IMPDH-I
      Background InformationInosine-5'-monophosphate dehydrogenase 1 (IMPDH 1) catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), as part of the de novo synthesis of guanine nucleotides. It therefore is crucial in the regulation of cell growth. IMPDH 1 may also have single-stranded nucleic acid-binding activity involving it in RNA and/or DNA metabolism, and is suspected to play a role in the growth progression of some tumors. Defects in IMPDH 1 abnormalities are linked to retinitis pigmentosa type 10 (RP10) and Leber congenital amaurosis type 11 (LCA11). Due to the connection between IMPDH activity and cell proliferation, it has been become a target for cancer and viral chemotherapy and immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly from mammalian enzymes, which make it a suitable target for anti-infective drugs.
      References
      Product Information
      FormatPurified
      Control
      • PC-12 cell lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IMPDH1 Antibody, clone 4F9.1 is a highly specific mouse monoclonal antibody, that targets Inosine-5'-monophosphate dehydrogenase 1 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected IMPDH1 in 10 µg of NIH3T3 cell lysate.
      Western Blotting Analysis: 1.0 µg/mL from a representative lot detected IMPDH1 in 10 µg of Jurkat cell lysate.
      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected IMPDH1 in rat eye tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human IMPDH1.
      Clone4F9.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IMPDH1
      • IMPD1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~55 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected IMPDH1 in 10 µg of PC-12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN291 04053252882937