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CBL1345 Anti-Integrin α2 Antibody, clone HMα2

Anti-Integrin α2 Antibody, clone HMα2 detects level of Integrin α2 & has been published & validated for use in FC, IF, IP, IH.

Anti-Integrin α2 Antibody, clone HMα2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGA2, CD49B, VLAA2, VLA-2, CD49b, BR, GPIa UniProt Number: P17301
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CBL1345
500 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IF, IP, IHCAHmPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL1345
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α2 Antibody, clone HMα2
      Alternate Names
      • CD49b
      Background InformationThe complex of CD49b associated with CD29 (integrin beta1) is a receptor for laminin and collagen. This complex is expressed by some CD4-positive T cells, natural killer cells, epithelial cells and platelets.
      References
      Product Information
      FormatPurified
      PresentationThe affinity chromatography purified monoclonal is presented in phosphate buffered saline, pH 7.2, containing 0.09% sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin α2 Antibody, clone HMα2 detects level of Integrin α2 & has been published & validated for use in FC, IF, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesFlowCytometry: = .5 μg per 10e6 cells in 100 μL volume

      Immunoprecipitation

      Immunofluorescence

      Immunohistochemistry

      Optimal working dilutions must be determined by the end user.
      Biological Information
      CloneHMalpha2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostArmenian Hamster
      SpecificitySpecifically recognizes the 150 kDa mouse CD49b, also known as Integrin alpha2.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA2
      • CD49B
      • VLAA2
      • VLA-2
      • CD49b
      • BR
      • GPIa
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
      SIZE: 1181 amino acids; 129295 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
      SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      CBL1345 04053252470615

      Documentation

      Anti-Integrin α2 Antibody, clone HMα2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin α2 Antibody, clone HMα2 Certificates of Analysis

      TitleLot Number
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] MONOCLONAL ANTIBODY - 2441448 2441448
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] - 3430396 3430396
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] - 3994082 3994082
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] -2733929 2733929
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] MONOCLONAL ANTIBODY - 2061624 2061624
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] MONOCLONAL ANTIBODY - 2329031 2329031
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] MONOCLONAL ANTIBODY -2499284 2499284

      Data Sheet

      Title
      HAMSTER ANTI-MOUSE INTEGRIN alpha2 [CD49b] MONOCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies