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MABS2001 Anti-LRP-1 Antibody, clone 11H4

Anti-LRP-1, clone 11H4, Cat. No. MABS2001, is a mouse monoclonal antibody that detects Prolow-density lipoprotein receptor-related protein 1 in human, mouse, and rat and has been tested for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blotting and Immunoprecipitation.

Anti-LRP-1 Antibody, clone 11H4 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: LRP1, A2MR, APR UniProt Number: Q07954
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MABS2001
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MIH(P), ICC, WB, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS2001
      DescriptionAnti-LRP-1 Antibody, clone 11H4
      Alternate Names
      • Prolow-density lipoprotein receptor-related protein 1
      • Alpha-2-macroglobulin receptor1
      • A2MR
      • Apolipoprotein E receptor
      • APOER
      • CD91
      Background InformationProlow-density lipoprotein receptor-related protein 1 (UniProt: Q07954; also known as LRP-1, Alpha-2-macroglobulin receptor1, A2MR, Apolipoprotein E receptor, APOER, CD91) is encoded by the LRP1 (also known as A2MR, APR) gene (Gene ID: 4035) in human. LRP-1 is expressed in most tissues, but is abundant in liver, brain, and lung. LRP1 is synthesized with a signal peptide sequence (a.a. 1-19) and is processed in trans-Golgi network by furin to generate a 515 kDa alpha subunit and an 85 kDa beta subunit. The alpha and beta subunits are non-covalently linked during LRP1 transport to the cell membrane. LRP-1 recognizes and mediates the endocytosis of more than 40 different ligands, including apolipoprotein E (ApoE), APP and amyloid beta. It is the primary receptor mediating transport of amyloid beta peptides across the blood-brain barrier into circulation, thereby clearing them from the brain. LRP-1 is required for early embryonic development and is involved in cellular lipid homeostasis and plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin). Excessive copper accumulation in the brain has been linked with reduced LRP-1 mediated clearance of amyloid beta peptides across the blood brain barrier, which may contribute to complications of Alzheimer's disease.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LRP-1, clone 11H4, Cat. No. MABS2001, is a mouse monoclonal antibody that detects Prolow-density lipoprotein receptor-related protein 1 in human, mouse, and rat and has been tested for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blotting and Immunoprecipitation.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected LRP-1 in human liver tissue.

      Immunoprecipitation Analysis: A representative lot detected LRP-1 in Immunoprecipitation applications (Nieves, E.C., et. al. (2010). J Biol Chem. 285(17):12595-603).

      Western Blotting Analysis: A representative lot detected LRP-1 in Western Blotting applications (Spoelgen, R., et. al. (2009). Neuroscience. 158(4):1460-8; Lleó, A., et. al. (2005). J Biol Chem. 280(29):27303-9; Campana, W.M., et. al. (2006). J Nuerosci. 26(43):11197-207).

      Immunocytochemistry Analysis: A representative lot detected LRP-1 in Immunocytochemistry applications (Lleó, A., et. al. (2005). J Biol Chem. 280(29):27303-9).

      Immunohistochemistry Analysis: A representative lot detected LRP-1 in Immunohistochemistry applications (Campana, W.M., et. al. (2006). J Nuerosci. 26(43):11197-207).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 13 amino acid from the C-terminal region on human LRP-1.
      Clone11H4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 11H4 detects LRP-1 protein in human, mouse, and rat tissues. It targets an epitope within 13 amino acids from the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LRP1
      • A2MR
      • APR
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight504.61 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human brain tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected LRP-1 in human brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS2001 04054839367212