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MABF2049 Anti-LTBR Antibody, clone 3C8

This rat monoclonal Anti-LTBR, clone 3C8, Cat. No. MABF2049, is tested for use in Flow Cytometry and in functional studies for the detection of Lymphotoxin-beta receptor/LTbeta R.

Anti-LTBR Antibody, clone 3C8 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Ltbr, Tnfcr, Tnfrsf3 UniProt Number: P50284
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MABF2049
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MAI, FCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF2049
      DescriptionAnti-LTBR Antibody, clone 3C8
      Alternate Names
      • Tumor necrosis factor receptor superfamily member 3
      • Lymphotoxin-beta receptor
      Background InformationTumor necrosis factor receptor superfamily member 3 (UniProt: P50284; also known as Lymphotoxin-beta receptor, LTBR) is encoded by the Ltbr (also known as Tnfcr, Tnfrsf3) gene (Gene ID: 17000) in murine species. The tumor necrosis factor (TNF) receptor superfamily comprises more than 20 type-I transmembrane proteins. LTBR is a single-pass type I membrane protein that contains 4 TNFR-Cys repeats and serves as a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. LTBR plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kB pathway. The binding of heterotrimeric lymphotoxin to LTBR is shown to induce NF-kB activation and cell death in HT29 adenocarcinoma cells. LTBR activation promotes apoptosis via TRAF3 and TRAF5. It is also reported to play a role in the development of lymphoid organs. Mice deficient in the LTBR gene fail to form lymph nodes and lack NK and NK-T cells. In the adults, LTBR signaling is essential for maintaining the splenic architecture, for the integrity of marginal zones, and for compartmentalization of T and B cells.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rat monoclonal Anti-LTBR, clone 3C8, Cat. No. MABF2049, is tested for use in Flow Cytometry and in functional studies for the detection of Lymphotoxin-beta receptor/LTbeta R.
      Key Applications
      • Agonist or Inhibitor
      • Flow Cytometry
      Application NotesAgonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Zhu, M., et. al. (2006). J Clin Invest. 116(11):2964-71).

      Flow Cytometry Analysis: A representative lot detected LTBR in Flow Cytometry applications (Yi, T., et. al. (2013). Elife. 2:e00757).

      Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Dejardin, E., et. al. (2002). Immunity. 17(4):525-35).

      Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Vondenhoff, M.F., et. al. (2009). J Immunol. 182(9):5439-45).

      Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Yi, T., et. al. (2013). Elife. 2:e00757).

      Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Banks, T.A., et. al. (2005). J Immunol. 174(11):7217-25).
      Biological Information
      ImmunogenLT betaR-Fc decoy protein.
      Clone3C8
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone 3C8 detects Tumor necrosis factor receptor superfamily member 3 in NIH3T3 cells.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ltbr
      • Tnfcr
      • Tnfrsf3
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight44.95 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in NIH/3T3 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected LTBR in one million NIH/3T3 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2049 04054839199318