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ABC851 Anti-MACC1 Antibody

Anti-MACC1 Antibody is an antibody against MACC1 for use in western blotting, IHC & immunofluorescence.

Anti-MACC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Gene Symbol: MACC1
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ABC851
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC851
      DescriptionAnti-MACC1 Antibody
      Alternate Names
      • Metastasis-associated in colon cancer protein 1
      • SH3 domain-containing protein 7a5
      • MACC1
      Background InformationMetastasis-associated in colon cancer protein 1, also known as SH3 domain-containing protein 7a5, and encoded by the gene name MACC1, is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway. This pathway is involved in cellular growth, epithelialmesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MACC1 Antibody is an antibody against MACC1 for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected MACC1 in human liver tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MACC1 in human liver cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human MACC1.
      Epitopecenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • MACC1
      Purification MethodAntigen Affinity Purified
      Molecular Weight~93 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Mouse liver tissue lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected MACC1 in Mouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC851 04053252943980