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MABC682 Anti-MATK Antibody, clone 9D7

Detect Megakaryocyte-associated tyrosine-protein kinase using this mouse monoclonal antibody, Anti-MATK Antibody, clone 9D7 validated for use in western blotting & Flow Cytometry.

Anti-MATK Antibody, clone 9D7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: MATK, CTK, HYL UniProt Number: P42679
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MABC682
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABC682
      DescriptionAnti-MATK Antibody, clone 9D7
      Alternate Names
      • Megakaryocyte-associated tyrosine-protein kinase
      • CSK homologous kinase
      • CHK
      • Hematopoietic consensus tyrosine-lacking kinase
      • Protein kinase HYL
      • Tyrosine-protein kinase CTK
      Background InformationMegakaryocyte-associated tyrosine-protein kinase (MATK), or alternatively CSK homologous kinase (CHK), Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, is an important kinase in hematopoietic signal transduction in blood cells as well as in other cells such as neurons and T cells. As its name would imply, MATK was first associated with megakaryocytes, the cells that give rise to platelets. MATK is able to phosphorylate and inactivate Src family kinases and may play a role in the regulation of proliferation of some cells such as T cells. In the nervous system MATK (called CHK in the older literature) plays a distinct role in the development of the CNS. MATK was found to be expressed in a developmental manner and expressed not only in developing neurons but also astrocytes and oligodendrocytes, but not in any of the associated tumors from these cell types, possibly indicating that it is the loss of expression of MATK activity that impacts tumorigenesis. EMD-Millipore’s Anti-MATK monoclonal antibody has been tested in western blot using K562 cell lysates and in flow cytometry using permeabilized K562 cells in culture.
      References
      Product Information
      FormatAscites
      Control
      • K562 cell lysate
      PresentationPurified mouse monoclonal liquid in PBS containing up to 0.1% sodium azide and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationDetect Megakaryocyte-associated tyrosine-protein kinase using this mouse monoclonal antibody, Anti-MATK Antibody, clone 9D7 validated for use in western blotting & Flow Cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected MATK in K562 cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified recombinant fragment of human MATK expressed in E. Coli.
      Clone9D7
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • MATK
      • CTK
      • HYL
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~56 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in K562 cell lysate.

      Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected MATK in K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC682 04053252920516