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AB3549P Anti-Monocarboxylate Transporter 8 Antibody

Anti-Monocarboxylate Transporter 8 Antibody is an antibody against Monocarboxylate Transporter 8 for use in ELISA & WB.

Anti-Monocarboxylate Transporter 8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SLC16A2, DXS128E, DXS128, MCT8, AHDS, XPCT, MCT7 UniProt Number: P36021
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AB3549P
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3549P
      ReplacesAB3324P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Monocarboxylate Transporter 8 Antibody
      Alternate Names
      • MCT8
      • X-linked PEST-containing Transporter
      Background InformationMCT8 is an integral membrane protein that is associated with the plasma membrane. A member of the Major Facilitator Superfamily, MCT8 serves as a proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates and ketone bodies across the plasma membrane. Expression of MCT8 is greatest in liver and kidney.
      References
      Product Information
      FormatAffinity Purified
      Control
      • POSITIVE CONTROL: Liver or kidney extracts
      PresentationAffinitypurified immunoglobulin presented as a liquid in PBS with 0.1% BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Monocarboxylate Transporter 8 Antibody is an antibody against Monocarboxylate Transporter 8 for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-5 μg/mL using ECL.
      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG202) per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 19 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse MCT8. The immunogen sequence is 94% conserved in rat and 89% in human MCT8 and shows no significant sequence homology with other MCT family members.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes mouse Monocarboxylate Transporter 8.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC16A2
      • DXS128E
      • DXS128
      • MCT8
      • AHDS
      • XPCT
      • MCT7
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36021 # Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
      SIZE: 539 amino acids; 59511 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Highly expressed in liver and heart.
      DISEASE: SwissProt: P36021 # Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.
      SIMILARITY: SwissProt: P36021 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB3549P 04053252329180