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MABT395 Anti-Muc4 Antibody, clone 8G7

Anti-Muc4 Antibody, clone 8G7 is a highly specific mouse monoclonal antibody, that targets Mucin & has been tested in western blotting & IHC.

Anti-Muc4 Antibody, clone 8G7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: MUC4 UniProt Number: E7EW47
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MABT395
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT395
      DescriptionAnti-Muc4 Antibody, clone 8G7
      Alternate Names
      • Mucin-4 beta chain
      Background InformationMucin-4 (MUC-4 or Muc4) is also called Ascites sialoglycoprotein (ASGP), Pancreatic adenocarcinoma mucin, Testis mucin, and Tracheobronchial mucin. Muc4 is proteolytically cleaved into two chains: mucin-4 alpha chain and mucin-4 beta chain. Muc4 has anti-adhesive properties and is involved in tumor progression, cell proliferation and differentiation of epithelial cells. Muc4 is expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, mammary and salivary glands as well as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, cervix cancers, pancreatic tumors, and pancreatic tumor cell lines. The expression of Muc4 has become a very useful indicator of poor prognosis in patients with invasive ductal carcinoma and intrahepatic cholangiocarcinoma, mass forming type (IDC,ICC-MF), where patients with high Muc4 expression had lower survival rates than those with low Muc4 expression.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Muc4 Antibody, clone 8G7 is a highly specific mouse monoclonal antibody, that targets Mucin & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Muc4 in human ilium tissues.

      Western Blotting Analysis: A representative lot from an independent laboratory detected Muc4 in maligant melanoma and cutaneous squamous cell carcinoma tissue lysates (Moniaux, N., et al. (2004). J Histochem Cytochem. 52(2):253-261.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Muc4 in lung adenocarcinoma and pancreatic adenocarcinoma tissues (Moniaux, N., et al. (2004). J Histochem Cytochem. 52(2):253-261.).

      Immunohistochemistry Analysis: A representative lot from independent laboratories detected Muc4 in 330 tissue spots representing normal skin, and benign and malignant cutaneous diseases (Singh, A. P., et al. (2006). Prostate. 66(4):421-429.; Chakraborty, S., et al. (2010). J Clin Pathol. 63(7):579-584.).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the beta chain tandem repeat region of human Muc4.
      Clone8G7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • MUC4
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~240 kDa observed. Uniprot describes a molecular weight at 430 kDa; however, this protein may be observed at ~240 kDa due to alternative spicing and post-translational modification (Moniaux, N., et al. (2004). J Histochem Cytochem. 52(2):253-261.).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in CD18/HPAF cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Muc4 in 10 µg of CD18/HPAF cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT395 04053252921919

      Documentation

      Anti-Muc4 Antibody, clone 8G7 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Muc4 Antibody, clone 8G7 Certificates of Analysis

      TitleLot Number
      Anti-Muc4, clone 8G7 3076931
      Anti-Muc4, clone 8G7 3113178
      Anti-Muc4, clone 8G7 - 3168730 3168730
      Anti-Muc4, clone 8G7 - 3241237 3241237
      Anti-Muc4, clone 8G7 - 3394692 3394692
      Anti-Muc4, clone 8G7 - 3401660 3401660
      Anti-Muc4, clone 8G7 - 3423725 3423725
      Anti-Muc4, clone 8G7 - 3475693 3475693
      Anti-Muc4, clone 8G7 - 3610590 3610590
      Anti-Muc4, clone 8G7 - 3739763 3739763
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