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481906 Anti-Nicastrin, N-Terminal (62-93) Rabbit pAb

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-SP716

481906
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the latent and active forms of nicastrin.
      Catalogue Number481906
      Brand Family Calbiochem®
      SynonymsAnti-SP716
      References
      ReferencesLeem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
      Yu, G., et al. 2000. Nature 407, 34.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunofluorescence
      Immunoprecipitation
      Application NotesImmunoblotting (1:1000-1:2000)
      Immunofluorescence (1:200)
      Immunoprecipitation (2 µl/mg protein)
      Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide (CQSSISGDTGVIHVVEKEEDLKWVLTDGPNPP) corresponding to amino acids 62-93 of human nicastrin, conjugated to KLH
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      481906 0

      Documentation

      Anti-Nicastrin, N-Terminal (62-93) Rabbit pAb Certificates of Analysis

      TitleLot Number
      481906

      References

      Reference overview
      Leem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
      Yu, G., et al. 2000. Nature 407, 34.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2007 RFH
      SynonymsAnti-SP716
      ApplicationImmunoblotting (1:1000-1:2000)
      Immunofluorescence (1:200)
      Immunoprecipitation (2 µl/mg protein)
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the latent and active forms of nicastrin.
      BackgroundNicastrin is a transmembrane glycoprotein that forms high molecular weight complexes with presensilin 1 and presensilin 2. It binds carboxy-terminal derivatives of beta-amyloid precursor protein (βAPP), and modulates the production of the amyloid β-peptide (Aβ) from these derivatives. Deposits of this amyloid beta-peptide form the amyloid plaques that characterize Alzheimer's disease.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide (CQSSISGDTGVIHVVEKEEDLKWVLTDGPNPP) corresponding to amino acids 62-93 of human nicastrin, conjugated to KLH
      IsotypeIgG
      Specieshuman, mouse
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesLeem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
      Yu, G., et al. 2000. Nature 407, 34.