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MABC698 Anti-PAWR, clone 3G9H7 Antibody

Detect PAWR using this Anti-PAWR, clone 3G9H7 Antibody validated for use in western blotting & IHC.

Anti-PAWR, clone 3G9H7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PAWR, PAR4 UniProt Number: Q96IZ0
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MABC698
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABC698
      DescriptionAnti-PAWR, clone 3G9H7 Antibody
      Alternate Names
      • PRKC apoptosis WT1 regulator protein
      • Prostate apoptosis response 4 protein
      • Par-4
      • PAWR
      Background InformationPRKC apoptosis WT1 regulator protein, also known as Prostate apoptosis response 4 protein (Par-4), and encoded by the gene name PAWR or PAR4, is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. PAWR levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. PAWR is localized to the cytoplasm in the absence of apoptosis signal and in normal cells and localized to the nucleus in most cancer cells. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. PAWR is a WT1 interacting protein that also functions as a transcriptional repressor.
      References
      Product Information
      FormatAscites
      PresentationMouse monoclonal IgG1 ascitic fluid with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect PAWR using this Anti-PAWR, clone 3G9H7 Antibody validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200-1:1,000 dilution from a representative lot detected PAWR in human brain and breast carcinoma tissues.
      Biological Information
      ImmunogenPurified recombinant fragment of human PAWR expressed in E. Coli
      Clone3G9H7
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • PAWR
      • PAR4
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Full-length Trx-PAWR recombinant protein and HeLa cell lysate.

      Western Blotting Analysis: A 1:500-1:2,000 dilution of this antibody detected PAWR in Full-length Trx-PAWR recombinant protein and HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC698 04053252955266

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies