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05-1417 Anti-PTP-PEST Antibody, clone AG25

Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.

Anti-PTP-PEST Antibody, clone AG25 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PTPN12, PTPG1, PTP-PEST, EC 3.1.3.48 UniProt Number: Q05209
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05-1417
100 µL  
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      Overview

      Replacement Information
      Replacement Information05-1417 is a recommended replacement for MAB3739

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IP, ICCMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-1417
      ReplacesMAB3739
      DescriptionAnti-PTP-PEST Antibody, clone AG25
      Alternate Names
      • Protein-tyrosine phosphatase G1
      • Tyrosine-protein phosphatase non-receptor type12
      • Protein tyrosine phosphatase, non-receptor type 12
      Background InformationThe protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
      References
      Product Information
      FormatAscites
      Control
      • HeLa cell lysate
      PresentationMouse monoclonal IgG1 ascites containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation: Recommended.

      Immunocytochemistry: Recommended.
      Biological Information
      ImmunogenBaculovirus expressed purified human PTP-PEST
      CloneAG25
      HostMouse
      SpecificityRecognizes human PTP-PEST.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
      Gene Symbol
      • PTPN12
      • PTPG1
      • PTP-PEST
      • EC 3.1.3.48
      UniProt Number
      UniProt SummarySIZE: 780 amino acids; 88120 Da
      SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
      SUBCELLULAR LOCATION: Cytoplasm.
      DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
      SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight~88 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on HeLa lysates.

      Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      05-1417 04053252368080