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MABN2395 Anti-Peripherin-2 Antibody, clone 2B7

Anti-Peripherin-2, clone 2B7, Cat. No. MABN2395, is a highly specific mouse monoclonal antibody that targets Peripherin-2/RDS and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.

Anti-Peripherin-2 Antibody, clone 2B7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Prph2, Rds UniProt Number: P15499
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MABN2395
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, BIF, WB, IH(P), ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN2395
      DescriptionAnti-Peripherin-2 Antibody, clone 2B7
      Alternate Names
      • Retinal degeneration slow protein
      Background InformationPeripherin-2 (UniProt: P15499; also known as Retinal degeneration slow protein) is encoded by the Prph2 (also known as Rds) gene (Gene ID: 19133) in murine species. Peripherin-2 is a multi-pass membrane glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It is localized to the photoreceptor disc rim region and is required for the initial formation and subsequent maintenance of both rod and cone outer segments. It can function as an adhesion molecule for stabilization and compaction of outer segment disks and the maintenance of the curvature of the rim. Mutations Prph2 gene are reported to cause incurable retinal degeneration. Peripherin-2 can form a wide variety of covalent and non-covalent homo- and heteromeric complexes and failure to oligomerize properly can result in protein degradation and retinitis pigmentosa.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Peripherin-2, clone 2B7, Cat. No. MABN2395, is a highly specific mouse monoclonal antibody that targets Peripherin-2/RDS and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Stuck, M.W., et. al. (2014). Hum Mol Genet. 23(23):6260-74).

      Immunofluorescence Analysis: A representative lot detected Peripherin-2 in Immunofluorescence applications (Chakraborty, D., et. al. (2010). Hum Mol Genet. 19(24):4799-812).

      Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).

      Immunocytochemistry Analysis: A representative lot detected Peripherin-2 in Immunocytochemistry applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 23 amino acids from the C-terminal region of murine Peripherin-2.
      EpitopeC-terminus
      Clone2B7
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 2B7 detects peripherin-2 in murine and bovine eye. It targets an epitope within 23 amino acids from the C-terminal end.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Bovine
      Species Reactivity NoteBovine, Mouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Prph2
      • Rds
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight39.26 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in the outer layer of photoreceptor cells of mouse eye tissue.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in the outer layer of photoreceptor cells of mouse eye tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN2395 04054839200977