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ABE1069 Anti-Polyhomeotic-like protein 2 Antibody (PHC2)

This Anti-Polyhomeotic-like protein 2 antibody is validated for use in WB, IH for the detection of Polyhomeotic-like protein 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: PHC2, EDR2, PH2 UniProt Number: Q8IXK0
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ABE1069
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1069
      DescriptionAnti-Polyhomeotic-like protein 2 Antibody (PHC2)
      Alternate Names
      • Polyhomeotic-like protein 2
      • hPH2
      • Early development regulatory protein 2
      Background InformationPolyhomeotic-like protein 2 (PHC2), also known as Polyhomeotic-like protein 2 hPH2, Early development regulatory protein 2, is encoded by the gene name PHC2, EDR2, and PH2. PHC2 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class of proteins required to maintain the transcription repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex has been shown to function via chromatin remodeling and modification of histones. It also mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expression. Polyhomeotic-like protein 2 PHC2 is a component of a Component of a PRC1-like complex. PHC2 has been demonstrated to interact with CBX4, BMI1, PCGF2, PHC1 and RNF2. In addition, PHC2 has been implied to interact with CHTOP and with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Polyhomeotic-like protein 2 antibody is validated for use in WB, IH for the detection of Polyhomeotic-like protein 2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Polyhomeotic-like protein 2 (PHC2) in human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Polyhomeotic-like protein 2 (PHC2) near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PHC2
      • EDR2
      • PH2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~35/85 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~91 kDa, ~88 kDa, ~30 kDa, and ~36 kDa which are all expected to cross react to this protein.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat kidney tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Polyhomeotic-like protein 2 (PHC2) in 10 µg of rat kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1069 04055977122343