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AB9906 Anti-QKI-6 Antibody

Anti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB.

Anti-QKI-6 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience, RNA Binding Protein (RBP) Gene Symbol: QKI, DKFZp586I0923, Hqk, QK3, QK, HKQ, HqkI UniProt Number: Q96PU8
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AB9906
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB9906
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-QKI-6 Antibody
      Alternate Names
      • Quaking Protein
      Background InformationQKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.
      References
      Product Information
      FormatSerum
      Control
      • Positive Control: Glial cells, astrocytes and oligodendrocytes.
      PresentationLiquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide from mouse QKI-6.
      HostRabbit
      SpecificityQKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryQKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]).[supplied by OMIM]
      Gene Symbol
      • QKI
      • DKFZp586I0923
      • Hqk
      • QK3
      • QK
      • HKQ
      • HqkI
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96PU8 # RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
      SIZE: 341 amino acids; 37671 Da
      SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
      TISSUE SPECIFICITY: Expressed in the frontal cortex of brain.
      PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
      DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors.
      SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB9906 04053252516320

      Documentation

      Anti-QKI-6 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-QKI-6 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-QKI-6 3073831
      RABBIT ANTI-QKI-6 POLYCLONAL ANTIBODY - 2161083 2161083
      RABBIT ANTI-QKI-6 - 3218248 3218248
      RABBIT ANTI-QKI-6 - 3386887 3386887
      RABBIT ANTI-QKI-6 - 3501837 3501837
      RABBIT ANTI-QKI-6 - 3723470 3723470
      RABBIT ANTI-QKI-6 - 4069784 4069784
      RABBIT ANTI-QKI-6 -2519235 2519235
      RABBIT ANTI-QKI-6 -2823647 2823647
      RABBIT ANTI-QKI-6 -2825517 2825517
      Show more

      References

      Reference overviewPub Med ID
      Protection of p27(Kip1) mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation
      Larocque, Daniel, et al
      Nat Neurosci, 8:27-33 (2005)  2005

      		15568022 15568022

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      Product Families

      Glial Cell Markers

      Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies