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06-018 Anti-ROR2 Antibody, CT

Anti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P).

Anti-ROR2 Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: BDB, BDB1 , EC 2.7.10.1 , MGC163394, NTRKR2, OTTHUMP00000021634, OTTHUMP00000063680 UniProt Number: Q01974
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06-018
400 µl  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-018
      DescriptionAnti-ROR2 Antibody, CT
      Alternate Names
      • Neurotrophic tyrosine kinase
      • receptor-related 2
      • neurotrophic tyrosine kinase receptor-related 2
      • receptor tyrosine kinase-like orphan receptor 2
      • tyrosine-protein kinase transmembrane receptor ROR2
      Background InformationReceptor tyrosine kinase-like orphan receptor 2, also known as ROR2, is a member of the Tyr protein kinase family and ROR subfamily of cell surface receptors. Located in the transmembrane, ROR2 is highly expressed during early embryonic development and is associated with chondrocyte formation, cartilage and growth plate maturity. Expression levels of ROR2 subside after 16 days and occur minimally in adults. ROR2 is post translationaly modified by ATM or ATR phosphorylation when DNA damage occurs. Mutations in ROR2 result in brachydactyly type B1 (BDB1), characterized by either hypoplasia or aplasia of the distal phalanges and nails. ROR2 is also associated with recessive Robinow syndrome (RRS), resulting in shortening of limbs, facial dysmorphia and spinal defects.
      References
      Product Information
      FormatPurified
      Control
      • Human gastric mucosa
      PresentationPurified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic linear peptide corresponding to the C-terminal region of ROR2
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminal region of ROR2.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq].
      Gene Symbol
      • BDB
      • BDB1
      • EC 2.7.10.1
      • MGC163394
      • NTRKR2
      • OTTHUMP00000021634
      • OTTHUMP00000063680
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION:Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

      Catalytic activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      Developmental stage Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7

      DISEASE: Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) [MIM:113000]. BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed.

      Defects in ROR2 are a cause of recessive Robinow syndrome (RRS) [MIM:268310]. RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. Ref.8 Ref.9

      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

      Contains 1 FZ (frizzled) domain.

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

      Contains 1 kringle domain.

      Contains 1 protein kinase domain.
      Molecular Weight~105 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by immunohistochemistry (paraffin) in human gastric mucosa.

      Immunohistochemistry(paraffin): 1:50-1:200 dilution of this antibody detected ROR2 in human gastric mucosa.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size400 µl
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      06-018 04053252728907