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ABS1026 Anti-Rab27B Antibody

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWB, IP, IHCRbSerumPolyclonal Antibody
      Catalogue NumberABS1026
      DescriptionAnti-Rab27B Antibody
      Alternate Names
      • Ras-related protein Rab-27B
      • C25KG
      Background InformationRAB27B, also known as C25KG, is a member of the Rab GTPase superfamily. RAB27B acts as a lipid anchoring protein that is prenylated and works in vesicular fusion and protein trafficking within cells. The protein is most highly expressed in testis but can be expressed in other cell types as well. Because Rab27B is widely expressed in various tissues together with Rab27A and RAB27B has been found to have the ability to bind all of the Rab27A effectors that have been tested, Rab27A and Rab27B were initially thought to function redundantly by sharing common Rab27 effectors. However, recent evidence has indicated that by interacting with different Rab27 effectors Rab27A and Rab27B play different roles in special types of secretion (e.g. exosome secretion and mast cell secretion) even within the same cell type. Rab27B is particularly important for regulating protein secretion by pancreatic acinar cells, for instance.
      Product Information
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationThis Anti-Rab27B Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunohistochemistry for the detection of Rab27B.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:1,000 dilution from a representative lot detected Rab27B in 10 µg of C2C12, mouse brain, and PC3 lysate.
      Western Blotting Analysis: A representative lot detected Rab27B in rat parotid gland lysate (Imai, A., et al. (2004). Journal of Cell Science. 117:1945-1953).
      Immunoprecipitation Analysis: A representative lot immunoprecipitated Rab27B in flg-Rab27B (Imai, A., et al. (2004). Journal of Cell Science. 117:1945-1953).
      Immunohistochemistry Analysis: A representative lot detected Rab27B in rat parotid acinar cells (Imai, A., et al. (2004). Journal of Cell Science. 117:1945-1953).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Rab27B.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RAB27B
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~27 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Rab27B in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1026 04055977052152


      Anti-Rab27B Antibody SDS


      Safety Data Sheet (SDS) 

      Anti-Rab27B Antibody Certificates of Analysis

      TitleLot Number
      Anti-Rab27B - Q2464800 Q2464800
      Anti-Rab27B - 3470157 3470157
      Anti-Rab27B -2734727 2734727
      Anti-Rab27B -2816649 2816649
      Anti-Rab27B Polyclonal Antibody 2898954
      Anti-Rab27B Polyclonal Antibody 3099687


      Reference overviewPub Med ID
      The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
      Imai, Akane, et al.
      J. Cell. Sci., 117: 1945-53 (2004)  2004

      Show Abstract
      15039459 15039459

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      Life Science Research > Antibodies and Assays > Primary Antibodies