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MABC119 Anti-Rab7A, clone 5G8.1 Antibody

Detect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.

Anti-Rab7A, clone 5G8.1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: RAB7A, RAB7 UniProt Number: P51149
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MABC119
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC119
      DescriptionAnti-Rab7A, clone 5G8.1 Antibody
      Alternate Names
      • Ras-related protein Rab-7a
      Background InformationRas-related protein Rab-7A (Rab7A, RAB7) is a small intracellular protein typically associated with cytoplasmic vesicles, phagosomes, and endosomes and is expressed in most cells but particularly high in muscle. It plays an important role in regulating the endo-lysosomal trafficking of proteins as well as in the endosomal trapping of pathogens and viruses. Besides endosome-lysosome trafficking, Rab7A functions in a variety of other critical cellular processes including nutrient uptake, growth factor mediated growth, neurotrophin transport, lipid transport, lysosome and phagosome maturation and development, as well as pathogen and virus innate immunity functions. RAB7A interacts with a number of other proteins within the cell, some important in endosome trafficking like RILP (Rab-interacting lysosomal protein) and CHM (Rab escort protein 1) others like RAC1 have a more pleiotropic impact and are part of many cellular processes, including the cell cycle, cell-cell adhesion, cytoskeletal motility, and cellular differentiation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab7A in human breast cancer and human cardiac myocytes and lymphocytes in human heart tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Rab7A.
      Clone5G8.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RAB7A
      • RAB7
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~23 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-MEL28 cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Rab7A in 10 µg of SK-MEL28 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC119 04053252975578