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AB5852 Anti-SHANK1a Antibody, NT

AB5852
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5852
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SHANK1a Antibody, NT
      Background InformationShank is a novel family of postsynaptic density proteins (PSD) that bind to PDS-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SHANK1a Antibody, N-terminus is an antibody against SHANK1a for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blotting: 1:500-1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the N-terminus of rat Shank1a.
      EpitopeN-terminus
      HostRabbit
      SpecificityRecognizes Shank1a, N-terminal.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SHANK1
      • SSTRIP
      • SPANK-1
      • Shank1
      • synamon
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y566 # Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
      SIZE: 2161 amino acids; 225021 Da
      SUBUNIT: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD- 95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity).TISSUE SPECIFICITY: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
      SIMILARITY: SwissProt: Q9Y566 ## Belongs to the SHANK family. & Contains 6 ANK repeats. & Contains 1 PDZ (DHR) domain. & Contains 1 SAM (sterile alpha motif) domain. & Contains 1 SH3 domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications