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PC527 Anti-Survivin (Ab-1) (1-12) Rabbit pAb

Anti-Survivin (Ab-1) (1-12) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC527
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~16 kDa survivin protein in MOLT-4 cells.
    • Antibody Target Gene Symbol: BIRC5
    • Target Synonym: AAC-11, AP14, API4, EPR-1, SURVIVIN, SURVIVIN 2B, Survivin delta ex3, survivin40, TIAP
    • Entrez Gene Name: baculoviral IAP repeat-containing 5
    • Hu Entrez ID: 332 (Related Antibodies: 574660)
    • Mu Entrez ID: 11799
    • Rat Entrez ID: 64041
      		•
      Catalogue NumberPC527
      Brand Family Calbiochem®
      Application Data
      Detection of human survivin by immunoblotting. Sample: Whole cell lysate from MOLT4 cells. Primary antibody: Anti-Survivin (Ab-1) (1-12) Rabbit pAb (Cat. No. PC527) (1 µg/ml) pre-incubated without blocking petide (lane A) or with blocking peptide (lane B). Detection: chemiluminescence.
      References
      ReferencesKobayashi, K., 1999. Proc. Natl. Acad. Sci. USA. 88, 1457.
      Li, F., et al. 1998. Nature 396, 580.
      Ambrosini, G., et al. 1997. Nat. Med. 3, 917.
      Product Information
      FormLiquid
      FormulationIn PBS.
      Positive controlMOLT4 cells
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:500-1:1000)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (MGAPTLPPAWQP) corresponding to amino acids 1-12 of human survivin
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC527 0

      Documentation

      Anti-Survivin (Ab-1) (1-12) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Survivin (Ab-1) (1-12) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC527

      References

      Reference overview
      Kobayashi, K., 1999. Proc. Natl. Acad. Sci. USA. 88, 1457.
      Li, F., et al. 1998. Nature 396, 580.
      Ambrosini, G., et al. 1997. Nat. Med. 3, 917.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2007 RFH
      ApplicationImmunoblotting (1:500-1:1000)
      Application Data
      Detection of human survivin by immunoblotting. Sample: Whole cell lysate from MOLT4 cells. Primary antibody: Anti-Survivin (Ab-1) (1-12) Rabbit pAb (Cat. No. PC527) (1 µg/ml) pre-incubated without blocking petide (lane A) or with blocking peptide (lane B). Detection: chemiluminescence.
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~16 kDa survivin protein.
      BackgroundApoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members of the TNF family, and prevented by inhibitor of apoptosis (IAP) proteins. IAP proteins, the products of a conserved gene family, bind to and inhibit cell death proteases. One novel IAP protein was recently identified and has been designated survivin. Survivin, a ~16 kDa protein, interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is predominantly expressed in the tissues of embryos, transformed cell lines, and in many human cancers and lymphomas.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide (MGAPTLPPAWQP) corresponding to amino acids 1-12 of human survivin
      IsotypeIgG
      Specieshuman
      Positive controlMOLT4 cells
      FormLiquid
      FormulationIn PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesKobayashi, K., 1999. Proc. Natl. Acad. Sci. USA. 88, 1457.
      Li, F., et al. 1998. Nature 396, 580.
      Ambrosini, G., et al. 1997. Nat. Med. 3, 917.