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MABN1193 Anti-Synaptophysin Antibody, clone 10F6.1

Anti-Synaptophysin Antibody, clone 10F6.1, Cat. No. MABN1193, is a highly specific monoclonal antibody that targets Synaptophysin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Synaptophysin Antibody, clone 10F6.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Syp UniProt Number: P07825
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MABN1193
50 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1193
      ReplacesMAB368
      DescriptionAnti-Synaptophysin Antibody, clone 10F6.1
      Alternate Names
      • Major synaptic vesicle protein p38
      Background InformationSynaptophysin (UniProt: P07825; also known as Major synaptic vesicle protein p38) is encoded by the Syp gene (Gene ID: 24804) in rat. Synaptophysin belongs to the synaptophysin/synaptobrevin family of proteins. It is one of the major glycoproteins present in presynaptic vesicles and in various neuroendocrine cells of both neuronal and epithelial phenotype. Its structure consists of a hexameric protein of four transmembrane spans with a short cytoplasmic amino and a long carboxy-terminal tail. Both amino- and carboxy-terminals are exposed on the cytoplasmic surface of the synaptic vesicle membrane. C-terminal domain of Snaptophysin is selectively required for the endocytosis during, but not after, cessation of sustained synaptic transmission. Synaptophysin is involved in organizing membrane components may regulate endocytosis to ensure vesicle availability following sustained neuronal activity. It is also involved in the regulation of short-term and long-term synaptic plasticity. Syp / neurons display functional deficiencies and slower recovery of the recycling synaptic vesicle pool. (Ref.: Kwon, SE and Chapman, ER (2011). Neuron. 70(5): 847 854).
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationPurified monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Synaptophysin Antibody, clone 10F6.1, Cat. No. MABN1193, is a highly specific monoclonal antibody that targets Synaptophysin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Synaptophysin in human cerebellum, human cerebral cortex, and human pancreatic tissues.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corrsponding to 86 amino acids from the C-terminal region of rat synaptophysin.
      Clone10F6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 10F6.1 detects synaptophysin in rat, human, and mouse brain. It targets a sequence within amino acids 222-307 in rat synaptophysin.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Syp
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~40 kDa observed; 33.31 kDa calculated. Glycosylated form displays higher molecular weight (~38 kDa). Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: A 1:50,000 dilution of this antibody detected Synaptophysin in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1193 04054839169595

      Documentation

      Anti-Synaptophysin Antibody, clone 10F6.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Synaptophysin Antibody, clone 10F6.1 Certificates of Analysis

      TitleLot Number
      Anti-Synaptophysin, clone 10F6.1 - 3438585 3438585
      Anti-Synaptophysin, clone 10F6.1 - 3766689 3766689
      Anti-Synaptophysin, clone 10F6.1 - 3850550 3850550
      Anti-Synaptophysin, clone 10F6.1 - 3870886 3870886
      Anti-Synaptophysin, clone 10F6.1 - 3915554 3915554
      Anti-Synaptophysin, clone 10F6.1 - 4264852 4264852
      Anti-Synaptophysin, clone 10F6.1 -Q2814934 Q2814934
      Anti-Synaptophysin, clone 10F6.1 Monoclonal Antibody 3055402
      Anti-Synaptophysin, clone 10F6.1 Monoclonal Antibody 2941469