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MABE430 Anti-TIP60 Antibody, clone 3F9

Anti-TIP60 Antibody, clone 3F9 is a highly specific mouse monoclonal antibody, that targets Tip60 & has been tested in western blotting & IHC.

Anti-TIP60 Antibody, clone 3F9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: TIP60, KAT5, HTATIP UniProt Number: P63279
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MABE430
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABE430
      DescriptionAnti-TIP60 Antibody, clone 3F9
      Alternate Names
      • Histone acetyltransferase KAT5
      • 60 kDa Tat-interactive protein
      • Tip60
      • Histone acetyltransferase HTATIP
      • HIV-1 Tat interactive protein
      • Lysine acetyltransferase 5
      • cPLA(2)-interacting protein
      Background InformationTIP60 protein or also known as Histone acetyltransferase KAT5, 60kDa Tat-interactive protein, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, or cPLA(2)-interacting protein and encoded by the KAT5/HTATIP/TIP60 gene is a histone acetyl transferase that forms the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of a number of genes via the acetylation of histone H4 and H2A. TIP60 plays a role in DNA repair, growth arrest and senescence, apoptosis, chromatin remodeling, and tumor suppression. First discovered as protein that interacted with HIV-1 Tat resulting in TIP60 becoming polyubiquitinated and degraded (which prevented apoptosis of the infected cell), TIP60 is now known to interact with a number of other intracellular proteins including HDAC7A, CREB1, BCL3, Androgen receptor and PLA2G4A. TIP60 is largely localized to the nucleus or nuclear envelope in most tissues. TIP60 is also necessary for oncogene and proto-oncogene mediated growth induction seen in many cancers. EMD-Millipore’s Anti-TIP60 mouse monoclonal antibody has been tested in western blot on recombinant TIP60 protein and in paraffin embedded immunohistochemistry on human liver carcinoma, rectum carcinoma, normal medulla and normal interbrain tissue sections.
      References
      Product Information
      FormatAscites
      Control
      • Human recombinant TIP60 protein
      PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TIP60 Antibody, clone 3F9 is a highly specific mouse monoclonal antibody, that targets Tip60 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected TIP60 in liver carcinoma, rectum carcinoma, normal medulla and interbrain tissues.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified recombinant fragment of human TIP60 expressed in E. Coli.
      Clone3F9
      HostMouse
      IsotypeIgG2b
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • TIP60
      • KAT5
      • HTATIP
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~60 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human recombinant TIP60 protein.

      Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected human recombinant TIP60 protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE430 04053252920530