05-521 Anti-TRF2 Antibody, clone 4A794

05-521
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-521
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TRF2 Antibody, clone 4A794
      Background InformationTRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.
      References
      Product Information
      FormatPurified
      Control
      • Positive Control Included: Jurkat cell lysate (12-303)
      PresentationProtein G Purified mouse IgG1 in PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus
      Clone4A794
      HostMouse
      SpecificityRecognizes TRF2.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
      Gene Symbol
      • TERF2
      • TRF2
      • TRBF2
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15554 # Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle.
      SIZE: 500 amino acids; 55551 Da
      SUBUNIT: Homodimer. Binds to RAP1. Interacts with NBN.
      SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
      TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q15554 ## Contains 1 HTH myb-type DNA-binding domain.
      Molecular Weight66 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-TRF2 Antibody, clone 4A794 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TRF2 Antibody, clone 4A794 Certificates of Analysis

      TitleLot Number
      Anti-TRF2, clone 4A7943071902
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1) - 21454252145425
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1) - 24447422444742
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1) - 24466892446689
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)3105747
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)2972814
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)2974953
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)3028811
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)3091214
      Anti-TRF2, clone 4A794 (mouse monoclonal IgG1)3028811A

      References

      Reference overviewApplicationPub Med ID
      Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.
      Koh, CM; Khattar, E; Leow, SC; Liu, CY; Muller, J; Ang, WX; Li, Y; Franzoso, G; Li, S; Guccione, E; Tergaonkar, V
      The Journal of clinical investigation  125  2109-22  2015

      Show Abstract
      25893605 25893605
      The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity.
      Ivanauskiene, K; Delbarre, E; McGhie, JD; Küntziger, T; Wong, LH; Collas, P
      Genome research  24  1584-94  2014

      Show Abstract
      25049225 25049225
      A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells.
      Wakai, M; Abe, S; Kazuki, Y; Oshimura, M; Ishikawa, F
      PloS one  9  e88530  2014

      Show Abstract
      Western Blotting24558398 24558398
      A new role for histone deacetylase 5 in the maintenance of long telomeres.
      Novo, Clara Lopes, et al.
      FASEB J., (2013)  2013

      Show Abstract
      23729589 23729589
      Cause-specific telomere factors deregulation in hepatocellular carcinoma.
      El Idrissi, M; Hervieu, V; Merle, P; Mortreux, F; Wattel, E
      Journal of experimental & clinical cancer research : CR  32  64  2013

      Show Abstract
      24020493 24020493
      DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin.
      Delbarre, E; Ivanauskiene, K; Küntziger, T; Collas, P
      Genome research  23  440-51  2013

      Show Abstract
      23222847 23222847
      Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
      Fumagalli, M; Rossiello, F; Clerici, M; Barozzi, S; Cittaro, D; Kaplunov, JM; Bucci, G; Dobreva, M; Matti, V; Beausejour, CM; Herbig, U; Longhese, MP; d'Adda di Fagagna, F
      Nature cell biology  14  355-65  2012

      Show Abstract
      22426077 22426077
      A siRNA-based screen for genes involved in chromosome end protection.
      Lackner, DH; Durocher, D; Karlseder, J
      PloS one  6  e21407  2011

      Show Abstract
      Immunofluorescence21760879 21760879
      Human RAP1 inhibits non-homologous end joining at telomeres.
      Sarthy J, Bae NS, Scrafford J, Baumann P
      EMBO J  28  3390-9. Epub 2009 Sep 17.  2009

      Show Abstract Full Text Article
      19763083 19763083
      Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.
      Ignacio Gonzalez-Suarez,Abena B Redwood,Stephanie M Perkins,Bart Vermolen,Daniel Lichtensztejin,David A Grotsky,Lucia Morgado-Palacin,Eric J Gapud,Barry P Sleckman,Teresa Sullivan,Julien Sage,Colin L Stewart,Sabine Mai,Susana Gonzalo
      The EMBO journal  28  2009

      Show Abstract Full Text Article
      19629036 19629036

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies