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MABS466 Anti-Trpv4 Antibody, clone 1B2.6

Anti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.

Anti-Trpv4 Antibody, clone 1B2.6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: VRL2, VROAC, TRPV4 UniProt Number: Q9HBA0
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MABS466
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS466
      DescriptionAnti-Trpv4 Antibody, clone 1B2.6
      Alternate Names
      • Trpv4
      • Transient receptor potential cation channel subfamily V member 4
      • TrpV4
      • Osm-9-like TRP channel 4
      • OTRPC4
      • Transient receptor potential protein 12
      • TRP12
      • Vanilloid receptor-like channel 2
      • Vanilloid receptor-like protein 2
      • VRL-2
      • Vanilloid receptor-related osmotically-activated channel
      • VR-OAC
      Background InformationTransient receptor potential cation channel subfamily V member 4 is a multitransmembrane non-selective cation channel encoded by the TRPV4 (also known as CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC) gene and belong to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the transient receptor potential (TRP)3 superfamily of channels. Ankyrin (ANK) repeats/domains are shown to be important for functional channel expression, and ANK domain mutations are found in patients suffering from Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and hereditary motor and sensory neuropathies (HMSN). (PMID 16293632, 20037587, 20037588).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 10 µg/mL from a representative lot detected Trpv4 in NIH/3T3 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Trpv4.
      Clone1B2.6
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityThis antibody is expected to react to all isoforms.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VRL2
      • VROAC
      • TRPV4
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~86-98 kDa observed. Uniprot describes 6 isoforms produced by alternative splicing ranging from ~86 to 98 kDa. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-MEL-28 cell lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected Trpv4 in 10 µg of SK-MEL-28 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS466 04055977145021

      Documentation

      Anti-Trpv4 Antibody, clone 1B2.6 Certificates of Analysis

      TitleLot Number
      Anti-Trpv4, clone 1B2.6 - 3182595 3182595
      Anti-Trpv4, clone 1B2.6 - 3224555 3224555
      Anti-Trpv4, clone 1B2.6 - 3462069 3462069
      Anti-Trpv4, clone 1B2.6 - 3781059 3781059
      Anti-Trpv4, clone 1B2.6 - 3822336 3822336
      Anti-Trpv4, clone 1B2.6 - 4095326 4095326
      Anti-Trpv4, clone 1B2.6 -2891852 2891852
      Anti-Trpv4, clone 1B2.6 -Q2559148 Q2559148
      Anti-Trpv4, clone 1B2.6 Monoclonal Antibody 3101501
      Anti-Trpv4, clone 1B2.6 Monoclonal Antibody MABS466
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      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.