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ABS1673 Anti-Uteroglobin

Detect Uteroglobin using this goat polyclonal Anti-Uteroglobin Antibody, Cat. No. ABS1673 that has been tested in Immunofluorescence, immunohistochemistry, and Western blotting.

Anti-Uteroglobin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: Scgb1a1, Cc10, Ugb, Utg UniProt Number: P17559
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ABS1673
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MIF, IHC, WBGtSerumPolyclonal Antibody
      Description
      Catalogue NumberABS1673
      DescriptionAnti-Uteroglobin
      Alternate Names
      • Clara cell phospholipid-binding protein
      • CCPBP
      • Clara cells 10 kDa secretory protein
      • CC10
      • PCB-binding protein
      • Secretoglobin family 1A member 1
      • Blastokinin
      Background InformationUteroglobin (UniProt: P17559; also known as Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Blastokinin) is encoded by the Scgb1a1 (also known as Cc10, Ugb, Utg) gene (Gene ID: 25575) in rat. Uteroglobin, is a member of the Secretoglobin superfamily that serves as a multifunctional protein and can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules. Uteroglobin is synthesized with a signal peptide of 19 amino acids and consists of a disulfide-linked dimer of two identical polypeptides, each polypeptide being composed of four helices. Uteroglobin derives its name from its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects. It is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways. It plays a role in sequestering pro-inflammatory mediators and carcinogens and has been implicated in the inhibition of cell migration and invasion. It inhibits soluble phospholipase A2 activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, phospholipids, prostaglandins, and retinols. Uteroglobin positive (Scgb1a1+) cells in different regions of the lung differ in their role as progenitors in vivo. For example, in the bronchioles, these cells can both self-renew and generate ciliated cells during postnatal growth and adult homeostasis. On the other hand, in the trachea, the majority of uteroglobin positive cells constitute a transient amplifying population during postnatal growth and steady state, and their capacity for self-renewal and multi-lineage differentiation increases in response to injury. (Ref.: Mukherjee, AB et al. (2007). Endocrine Rev. 28(7): 707-725).
      References
      Product Information
      FormatSerum
      PresentationGoat polyclonal antiserum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Uteroglobin using this goat polyclonal Anti-Uteroglobin Antibody, Cat. No. ABS1673 that has been tested in Immunofluorescence, immunohistochemistry, and Western blotting.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunofluorescence Analysis: A representative lot detected Uteroglobin in dedifferentiated cells (Tata, P.R., et. al. (2013). Nature. 503(7475):218-23) and mice E18.5 lung tissue (Hashimoto, S., et. al. (2012). J Cell Sci. 125(Pt 4):932-42).

      Immunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Uteroglobin in mouse lung tissue. (Courtesy of Dr.Barry Stripp at Cedars-Sinai Medical Center, Los Angeles, CA).

      Immunohistochemistry Analysis: A representative lot detected Uteroglobin in adult mice alveoli (Rawlins, E.L., et. al. (2009). Cell Stem Cell. 4(6):525-34).
      Biological Information
      ImmunogenHis-tagged full length recombinant rat uteroglobin.
      Epitopeunknown
      ConcentrationPlease refer to lot specific datasheet.
      HostGoat
      SpecificityThis polyclonal antibody detects uteroglobin in mouse and rat tissues.
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Scgb1a1
      • Cc10
      • Ugb
      • Utg
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~10 kDa observed; 10.45 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse lung tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected Uteroglobin in 10 µg of mouse lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1673 04054839176418