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NE1024 Anti-p75 Neurotrophin Receptor Rabbit pAb

This Anti-p75 Neurotrophin Receptor Rabbit pAb is validated for use in Immunoblotting, Immunocytochemistry for the detection of p75 Neurotrophin Receptor.

Anti-p75 Neurotrophin Receptor Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
NE1024
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, RRbPolyclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~75 kDa neurotrophin receptor (p75NTR) protein in cultured mouse fibroblasts stably transfected with human p75NTR. Also recognizes additional lower MW proteins that are cleavage products of p75NTR.
      Catalogue NumberNE1024
      Brand Family Calbiochem®
      Application Data
      Detection of human p75 neurotrophin receptor by immunoblotting. Samples: Whole cell lysate (30 µg) from mouse fibroblasts stably tranfected with human p75NTR (Lane 1) and HEK293 cells transiently transfected with human p75NTR (Lane 2). Primary antibody: Anti-p75 Neurotrophin Receptor Rabbit pAb (Cat. No. NE1024) (1-2 µg/ml). Detection: chemiluminescence.
      References
      ReferencesKanning, K.C., et al. 2003. J. Neurosci. 23, 5425.
      Product Information
      FormLiquid
      FormulationIn PBS.
      Positive controlMouse fibroblasts stably transfected with human p75NTR
      Preservative0.03% thimerosal
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunocytochemistry
      Application NotesImmunoblotting (1-2 µg/ml)
      Immunocytochemistry (1-5 µg/ml)
      Application CommentsThe immunogen sequence comprises the C-terminal intracellular domain. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena recombinant protein consisting of amino acids 273-425 of rat p75NTR
      ImmunogenRat
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Mercury prohibited To comply with ban of sale of mercury-added products required by The Interstate Mercury Education and Reduction Clearinghouse (IMERC), this product is prohibited to be sold in the following US states: Rhode Island and Connecticut.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      NE1024 0

      Documentation

      Anti-p75 Neurotrophin Receptor Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-p75 Neurotrophin Receptor Rabbit pAb Certificates of Analysis

      TitleLot Number
      NE1024

      References

      Reference overview
      Kanning, K.C., et al. 2003. J. Neurosci. 23, 5425.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-May-2011 JSW
      ApplicationImmunoblotting (1-2 µg/ml)
      Immunocytochemistry (1-5 µg/ml)
      Application Data
      Detection of human p75 neurotrophin receptor by immunoblotting. Samples: Whole cell lysate (30 µg) from mouse fibroblasts stably tranfected with human p75NTR (Lane 1) and HEK293 cells transiently transfected with human p75NTR (Lane 2). Primary antibody: Anti-p75 Neurotrophin Receptor Rabbit pAb (Cat. No. NE1024) (1-2 µg/ml). Detection: chemiluminescence.
      DescriptionPurified rabbit polyclonal antibody. Recognizes the ~75 kDa p75 neurotrophin receptor protein.
      BackgroundNeurotrophins are a family of proteins that interact with neurotrophin receptors and provide various survival signals in nervous tissue. p75 neurotrophin receptor (p75NTR) is also known as the low-affinity neurotrophin receptor, while TrkA, TrkB, and TrkC are the high affinity receptors. p75NTR is a member of the tumor necrosis factor receptor family and is common to all neurotrophins. Similar to the high affinity receptors, p75NTR will bind the neurotrophins, but unlike the Trk proteins, it has no cytoplasmic tyrosine kinase domain. The roles of this receptor are controversial, as it may also be involved in either promoting or downregulating the response to the neurotrophins. It may also function to increase the affinity of the trk receptors for their respective neurotrophins or it may bind neurotrophins and prevent them from binding to the high affinity receptors. p75NTR does not have a catalytic intracellular tyrosine kinase domain, but it is still capable of mediating the neurotrophin signals.
      HostRabbit
      Immunogen speciesRat
      Immunogena recombinant protein consisting of amino acids 273-425 of rat p75NTR
      IsotypeIgG
      Specieshuman, rat
      Positive controlMouse fibroblasts stably transfected with human p75NTR
      FormLiquid
      FormulationIn PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative0.03% thimerosal
      CommentsThe immunogen sequence comprises the C-terminal intracellular domain. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesKanning, K.C., et al. 2003. J. Neurosci. 23, 5425.