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ABE155 Anti-phospho Histone H3.1/H3.2 Antibody (Ser87)

Detect Histone H3 using this rabbit polyclonal antibody, Anti-phospho Histone H3.1/H3.2 Antibody (Ser87) validated for use in western blotting & Dot Blot.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: SNCA, NACP, PARK1 UniProt Number: P68431
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ABE155
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, BWB, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE155
      DescriptionAnti-phospho Histone H3.1/H3.2 Antibody (Ser87)
      Alternate Names
      • Alpha-synuclein
      • Non-A beta component of AD amyloid
      • Non-A4 component of amyloid precursor
      • NACP
      Background InformationHistone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone H3.1, H3.2 and H3.3 are all closely related Histone H3 variants, that despite differing by only a few amino acids have been shown to have different functional roles.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa acid extract
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Histone H3 using this rabbit polyclonal antibody, Anti-phospho Histone H3.1/H3.2 Antibody (Ser87) validated for use in western blotting & Dot Blot.
      Key Applications
      • Western Blotting
      • Dot Blot
      Application NotesDot Blot (Specificity) Analysis: 1µg/mL of this antibody detected phospho Histone H3.1/H3.2 (Ser87) in a panel of unmodified and modified Histones.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Histone H3.1/H3.2 phosphorylated at Ser87.
      EpitopePhosphorylated at Ser87
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Histone H3.1/H3.2 phosphorylated at Ser87. This antibody demonstrates specificity for phospho Histone H3.1/H3.2 (Ser87), but does not cross react with phospho Histone H3.3, or any other modified and non-modified histones.
      Species Reactivity
      • Human
      • Mouse
      • Bovine
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SNCA
      • NACP
      • PARK1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Colcemid treated HeLa acid extract.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected phospho Histone H3.1/H3.2 (Ser87) in 10 µg of Colcemid treated HeLa acid extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE155 04053252910623