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MABE270 Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: STAT6 UniProt Number: P42226
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MABE270
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE270
      DescriptionAnti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1
      Alternate Names
      • Signal transducer and activator of transcription 6
      • IL-4 Stat
      Background InformationSignal transducer and activator of transcription 6 (STAT6) transduces signals from extracellular cytokines during adaptive immunity and has recently been found to be important in the innate immune response to viral infection. STAT6 is also involved in the attenuation of the Th1 and Th17 in the nephritogenic immune response. The consequence of STAT6 activity has been associated with the pathogenesis of autoimmune disease and has been found to be actively imported to the nucleus.
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 cell lysates treated and untreated with PDGF
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 2 µg/mL from a representative lot detected STAT6 in human peripheral blood leukocytes.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human STAT6 phosphorylated at (Tyr641).
      EpitopePhosphorylated (Tyr641)
      Clone19E2.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes STAT6 phosphorylated at (Tyr641).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
      Gene Symbol
      • STAT6
      Modifications
      • Phosphorylation
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

      SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with NCOA1 via its C-terminal LXXLL motif.

      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

      PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL-3 (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

      Contains 1 SH2 domain.
      Molecular Weight~165 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysates treated and untreated with PDGF.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected STAT6 on 10 µg of PDGF untreated and treated NIH/3T3 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE270 04053252686856

      Documentation

      Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 Certificates of Analysis

      TitleLot Number
      Anti-phospho STAT6 (Tyr641), -2636743 2636743
      Anti-phospho STAT6 (Tyr641), -2686154 2686154
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2204985 2204985
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2290257 2290257
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 2349709 2349709
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 - 3901432 3901432
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 - N1956541 N1956541
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 Monoclonal Antibody 3097348
      Anti-phospho STAT6 (Tyr641), clone 19E2.1 Monoclonal Antibody 2981047

      Brochure

      Title
      New Products: Volume 3, 2012

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies