178197 Sigma-AldrichAntimycin A
This product has been discontinued.
A cell-permeable compound (70 µM) that is shown to increase the percentage of Calu-6 cells, which display a loss in MMP (ΔΨm) by ~ 33%, the percentage of cells arrested in the sub-G1 phase by ~ 14%, the percentage of GSH-depleted cells by ~ 21%, the mean superoxide anion radical levels by ~ 175%, and inhibit the growth the same cultures by up to ~ 80% over controls. In general, co-treatment with a p38-, JNK-, or MEK-MAPK inhibitor is demonstrated to magnify the effects of compound alone in Calu-6 cultures, with some exceptions. (Please refer to our complete listing of MAPK Inhibitors). In patch clamp studies, 2 µM of Antimycin A (AMA) is shown to inhibit the activities of the 10 pS channel and the MCC of the inner mitochondrial membrane, but promotes the opening of both channels at much higher concentrations in a reversible manner. Also is found to inhibit the growth of A549 cells via inducing cell cycle arrest and maintain the pluripotency of hESCs at concentrations of 2-100 µM and 20 nM, respectively. This compound is known to inhibit succinate oxidase, NADH oxidase, and mitochondrial electron transport chain between cytochrome b and c.
|References||Han, Y.H., et al. 2010. Mol. Cell. Biochem. 333, 211; Varum, S., et al. 2009. Stem Cell Res. 3, 142; Han, Y., et al. 2008. Oncol. Rep. 20, 689; Campo, H.L., et al. 1992. J. Biol. Chem. 12, 8123;|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|