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181198 Arachidonic Acid - CAS 506-32-1 - Calbiochem

Precursor for prostaglandins, prostacyclin, and thromboxane.

Arachidonic Acid - CAS 506-32-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, 20:4

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181198
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
506-32-1C₂₀H₃₂O₂

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181198-100MG
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      		 Glass bottle 100 mg
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      181198-1GM
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          		 Plastic ampoule 1 gm
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          Description
          OverviewPrecursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.
          Catalogue Number181198
          Brand Family Calbiochem®
          Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, 20:4
          References
          ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
          Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
          Han, J.-W., et al. 1991. Science 252, 576.
          Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
          Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.
          Product Information
          CAS number506-32-1
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₂₀H₃₂O₂
          Chemical formulaC₂₀H₃₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetRas-GAP
          Purity≥99% by TLC and GC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCE6675000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 36-26

          Wear suitable protective clothing.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful
          Storage ≤ -70°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          181198-100MG 04055977205008
          181198-1GM 04055977204995

          Documentation

          Arachidonic Acid - CAS 506-32-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Arachidonic Acid - CAS 506-32-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          181198

          References

          Reference overview
          Hallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
          Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
          Han, J.-W., et al. 1991. Science 252, 576.
          Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
          Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, 20:4
          DescriptionA cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
          FormColorless oil
          Intert gas (Yes/No) Packaged under inert gas
          CAS number506-32-1
          RTECSCE6675000
          Chemical formulaC₂₀H₃₂O₂
          Structure formulaStructure formula
          Purity≥99% by TLC and GC
          SolubilityEthanol (5 mg/ml)
          Storage Protect from light
          ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful
          Merck USA index14, 765
          ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
          Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
          Han, J.-W., et al. 1991. Science 252, 576.
          Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
          Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.