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189401 Aurothiomalate

A gold(I) compound that inhibits the activity of IKK and disrupts PB1 domain-mediated interactions between Par6 and PKCι.

Aurothiomalate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aurothiomalate, Sodium Salt, AuTM, ATM

189401
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      12244-57-4C₄H₄AuNaO₄S
      Description
      Overview

      This product has been discontinued.




      A gold(I) compound that inhibits the activity of IKK (ID50 = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCι (IC50 = ~ 1 µM) by modifying cysteine residues within the catalytic domain of IKK and the PB1 domain of PKCι. Inhibits PKCι-dependent Rac1 activation in A549 cells.
      Catalogue Number189401
      Brand Family Calbiochem®
      SynonymsAurothiomalate, Sodium Salt, AuTM, ATM
      References
      ReferencesErdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
      Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
      Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
      Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.
      Product Information
      CAS number12244-57-4
      FormOff-white solid
      Hill FormulaC₄H₄AuNaO₄S
      Chemical formulaC₄H₄AuNaO₄S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% (Gold content)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      189401 0

      Documentation

      Aurothiomalate Certificates of Analysis

      TitleLot Number
      189401

      References

      Reference overview
      Erdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
      Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
      Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
      Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsAurothiomalate, Sodium Salt, AuTM, ATM
      DescriptionA gold(I) compound that blocks NF-κB activation and PKCι-dependent Rac1 signaling and displays antitumor properties. Modifies metal sensitive cysteine residues of IKK and PKCι, and inhibits the activity of IKK (ID50 = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCι (IC50 ~ 1 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number12244-57-4
      Chemical formulaC₄H₄AuNaO₄S
      Structure formulaStructure formula
      Purity≥98% (Gold content)
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 4518
      ReferencesErdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
      Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
      Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
      Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.