197223 Sigma-AldrichBcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem

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Synonyms: 5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II

197223

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Key Spec Table

CAS #	Empirical Formula
607702-99-8	C₁₆H₁₁F₂N₃OS₂

Description
Overview	This product has been discontinued. A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (K_i = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr²⁴⁵ phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
Catalogue Number	197223
Brand Family	Calbiochem®
Synonyms	5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II

References
References	Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.

Product Information
CAS number	607702-99-8
Form	White solid
Hill Formula	C₁₆H₁₁F₂N₃OS₂
Chemical formula	C₁₆H₁₁F₂N₃OS₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

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Title
PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem Certificates of Analysis

Title	Lot Number
197223	Enter Lot Number

References

Reference overview
Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-May-2011 RFH
Synonyms	5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
Description	A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (K_i = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr²⁴⁵ phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	607702-99-8
Chemical formula	C₁₆H₁₁F₂N₃OS₂
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Toxicity	Standard Handling
References	Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.