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201125 Binucleine 2 - CAS 220088-42-6 - Calbiochem

Binucleine 2 - CAS 220088-42-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      220088-42-6C₁₃H₁₁ClFN₅
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyrazolo compound that inhibits cytokinesis function of the Aurora B kinase pathway. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, while inactive in mammalian systems. Does neither function as a general kinase inhibitor nor inhibit Cdk-dependent entry into mitosis.
      Catalogue Number201125
      Brand Family Calbiochem®
      SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
      References
      ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
      Product Information
      CAS number220088-42-6
      FormBrown solid
      Hill FormulaC₁₃H₁₁ClFN₅
      Chemical formulaC₁₃H₁₁ClFN₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      201125 0

      Documentation

      Binucleine 2 - CAS 220088-42-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Binucleine 2 - CAS 220088-42-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      201125

      References

      Reference overview
      Eggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-February-2008 JSW
      SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
      DescriptionA cell-permeable pyrazolo compound that inhibits the cytokinesis function of the Aurora B kinase pathway. Shown to inhibit Aurora β-dependent phosphorylation, but not a general kinase inhibitor. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, but is inactive in mammalian systems. Inhibit Cdk-dependent entry into mitosis.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220088-42-6
      Chemical formulaC₁₃H₁₁ClFN₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.