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SCT264 BioTracker™ Mitophagy Live Cell Probe

SCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer's and Parkinson's.

SCT264
15 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT264
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      DescriptionBioTracker™ Mitophagy Live Cell Probe
      OverviewThe Mitophagy probe accumulates in intact mitochondria, where it is immobilized by chemical bonds and exhibits a weak fluorescence under normal conditions. When mitophagy is induced, the damaged mitochondria fuse with the lysosome, increasing fluorescence


      SPECTRAL PROPERTIES
      λex: 530 nm
      λem: 700 nm

      A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
      A typical working solution concentration is 1 nM.
      Alternate Names
      • mitophagy probe
      • mitophagy detection
      • mitochondrial degradation probe
      Background InformationMitochondria play an essential role in cells for the production of energy. Mitophagy, or the removal of damaged mitochondria via autophagy, has been connected to Alzheimer s and Parkinson s disease induced by the accumulation of depolarized mitochondria. Mitophagy serves as a dedicated elimination system that removes mitochondria whose dysfunction may be caused by oxidative stress and DNA damage. Mitochondria destined for autophagy are sequestered into the autophagosome, fused to the lysosome, and digested.
      References
      Product Information
      FormatLyophilized solid
      Presentationpurple solid
      Quality LevelMQ100
      Applications
      ApplicationSCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer's and Parkinson's.
      Key Applications
      • Mitochondria imaging
      • Cell Based Assays
      • Fluorescence
      Application NotesThis far red live cell probe for mitophagy detection fluoresces brightly when damaged mitochondria enter the acidic environment of the lysosome.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2 - 8 °C, protected from light.
      Packaging Information
      Material Size15 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT264 04065270661319

      Documentation