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SCT038 BioTracker Orange OH and HClO Dye

Live cell imaging probe to detect hydroxy radical (OH) or hypochlorous acid (HClO) in live cells.

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SCT038
5 x 100 nmol  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT038
      DescriptionBioTracker Orange OH and HClO Dye
      OverviewReactive oxygen species (ROS) are important mediators in a variety of biological and pathological events. For example, ROS generated in mitochondria play important roles in the modulation of signal transduction cascades and transcription factors. However, oxidative stress due to excessive generation of ROS is implicated in many human diseases, including acute and chronic inflammatory processes, ischemic stroke, diabetes, sepsis, ischemia-reperfusion injury, atherosclerosis, and neurodegenerative disorders.

      BioTracker Orange OH and HClO Dye is an orange fluorescent probe to detect hydroxy radical (・OH) or hypochlorous acid (HClO) in live-cell imaging. It can detect -OH and HClO among other reactive oxygen species (O2-, H2O2, NO, ONOO-). Its nearly red fluorescence spectrum allows multicolor imaging with green (ex. GFP, FITC) and blue (ex. Hoechst 33342) fluorophores. Because of its positive charge, OxiORANGE™ tends to localize within mitochondria. It has high photostability and is suitable for time-lapse imaging of intracellular hROS generation.

      Spectral Properties
      Absorbance (max): 553m
      Emission (max): 577nm

      References
      Koide Y et al. Design and Synthesis of Fluorescent Probes for Selective Detection of Highly Reactive Oxygen Species in Mitochondria of Living Cells. J. Am. Chem Soc. 2007, 129, 34, 10324-10325.
      Alternate Names
      • OxiORANGE™
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging probe to detect hydroxy radical (OH) or hypochlorous acid (HClO) in live cells.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging. Red/Orange fluorescence spectrum.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 95% (LC)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker Orange OH and HClO Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size5 x 100 nmol
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT038 04061841588245