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SCT056 BioTracker™ QUMA-1 RNA G-quadruplex Live Cell Dye

A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.

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SCT056
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT056
      DescriptionBioTracker™ QUMA-1 RNA G-quadruplex Live Cell Dye
      OverviewRNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions: telomere elongation, DNA recombination, transcription, RNA post-transcriptional mechanisms (pre-mRNA processing, mRNA turnover, targeting and translation), and are associated with sevral human diseases.

      BioTracker™ QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.

      Spectral Properties
      Absorbance: 555 nm
      Emission: 660 nm

      References
      Chen X et al. Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells. Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4702-4706.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationA red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 628.17 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker QUMA-1 RNA G-quadruplex -Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT056 04054839736322