236608 C-Reactive Protein, Human, Recombinant, E. coli

236608
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236608-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewRecombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.
      M.W. 23,000 (monomer); 115,000 (pentamer).
      Catalogue Number236608
      Brand Family Calbiochem®
      SynonymsrhCRP
      References
      ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
      Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
      Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
      Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
      de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.
      Product Information
      CAS number9007-41-4
      FormLiquid
      FormulationIn 140 mM NaCl, 20 mM Tris-HCl, 2 mM CaCl₂, 0.05% NaN₃, pH 7.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      C-Reactive Protein, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      C-Reactive Protein, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      236608

      References

      Reference overview
      Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
      Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
      Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
      Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
      de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.

      Citations

      Title
    • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
    • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-February-2014 JSW
      SynonymsrhCRP
      DescriptionRecombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
      FormLiquid
      FormulationIn 140 mM NaCl, 20 mM Tris-HCl, 2 mM CaCl₂, 0.05% NaN₃, pH 7.5.
      CAS number9007-41-4
      SolubilityAqueous buffers
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Toxicity Standard Handling
      Merck USA index14, 2603
      ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
      Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
      Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
      Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
      de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.
      Citation
    • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
    • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.