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227013 CCR4 Antagonist - CAS 864289-85-0 - Calbiochem

The CCR4 Antagonist, also referenced under CAS 864289-85-0, controls the biological activity of CCR4. This small molecule/inhibitor is primarily used for Membrane applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      864289-85-0C₂₇H₄₁N₅O₂ • 0.5 H₂O
      Description
      OverviewA cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
      Catalogue Number227013
      Brand Family Calbiochem®
      Synonyms2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
      References
      ReferencesYokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.
      Product Information
      CAS number864289-85-0
      FormLight beige solid
      Hill FormulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
      Chemical formulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      227013 0

      Documentation

      CCR4 Antagonist - CAS 864289-85-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CCR4 Antagonist - CAS 864289-85-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      227013

      References

      Reference overview
      Yokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
      DescriptionA cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number864289-85-0
      Chemical formulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesYokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.