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219676 CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      774549-97-2C₁₉H₁₇Cl₂N₃O₂S
      Description
      OverviewA cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
      Catalogue Number219676
      Brand Family Calbiochem®
      Synonyms7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
      References
      ReferencesRobert, R., et al. 2008. Mol. Pharmacol. 73, 478.
      Product Information
      CAS number774549-97-2
      FormWhite solid
      Hill FormulaC₁₉H₁₇Cl₂N₃O₂S
      Chemical formulaC₁₉H₁₇Cl₂N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219676 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      219676

      References

      Reference overview
      Robert, R., et al. 2008. Mol. Pharmacol. 73, 478.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
      DescriptionA cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 & 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number774549-97-2
      Chemical formulaC₁₉H₁₇Cl₂N₃O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRobert, R., et al. 2008. Mol. Pharmacol. 73, 478.