233554 COCO, Mouse, Recombinant

233554
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥90% by SDS-PAGE
      Description
      Overview

      This product has been discontinued.





      Recombinant, mouse COCO, consisting of amino acids 24-185 and expressed in E. coli. COCO, a member of the DAN Domain family of BMP antagonists, is able to bind to Xnr1, BMP-4, activin, and Wnt8.
      Catalogue Number233554
      Brand Family Calbiochem®
      SynonymsDAND5 Dante CKTSF1B3
      References
      ReferencesVonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
      Baron, M.H. 2005. Exp. Hematol. 33, 1015.
      Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
      Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
      AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
      De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
      Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
      Bell, E. et al. 2003. Development 130, 1381.
      Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.
      Product Information
      FormSolid
      FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, and BSA.
      Applications
      Biological Information
      Biological activityED₅₀ = 0.6-3 µg/ml as determined by inhibition of BMP-4-induced activity (50 ng/ml BMP-4) in MC3T3-E1 mouse osteoblastic cells.
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      COCO, Mouse, Recombinant Certificates of Analysis

      TitleLot Number
      233554

      References

      Reference overview
      Vonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
      Baron, M.H. 2005. Exp. Hematol. 33, 1015.
      Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
      Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
      AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
      De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
      Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
      Bell, E. et al. 2003. Development 130, 1381.
      Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-Sepmtember-2011 RFH
      SynonymsDAND5 Dante CKTSF1B3
      DescriptionRecombinant, mouse COCO, consisting of amino acids 24-185 and expressed in E. coli. COCO, a member of the DAN Domain family of BMP antagonists, is able to bind to Xnr1, BMP-4, activin, and Wnt8.
      FormSolid
      FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, and BSA.
      Purity≥90% by SDS-PAGE
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Biological activityED₅₀ = 0.6-3 µg/ml as determined by inhibition of BMP-4-induced activity (50 ng/ml BMP-4) in MC3T3-E1 mouse osteoblastic cells.
      SolubilityReconstitute to 100 µg/ml in sterile 35% Acetonitrile, 0.1% TFA containing at least 0.1% human or bovine serum albumin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
      Baron, M.H. 2005. Exp. Hematol. 33, 1015.
      Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
      Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
      AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
      De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
      Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
      Bell, E. et al. 2003. Development 130, 1381.
      Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.