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851085 COMU

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851085
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
1075198-30-9C₁₂H₁₉F₆N₄O₄P428.27 g/mol
Description
Catalogue Number851085
Brand Family Novabiochem®
Alternate Names
  • 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
Background InformationCOMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1, 2].

It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3].
References
Product Information
CAS number1075198-30-9
Hill FormulaC₁₂H₁₉F₆N₄O₄P
Molar Mass428.27 g/mol
HS Code2934 99 99
Structure formula ImageStructure formula Image
Quality LevelMQ300
Applications
ApplicationCOMU 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®. CAS 1075198-30-9, molar mass 428.27 g/mol.
Biological Information
Physicochemical Information
Melting Point159 - 160 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 99.0 % (a/a)
Solubility (10% in acetonitrile)clear

Documentation

COMU SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
  • [2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
  • [3] Jean-d'Amour, et al. (2011) Org. Lett., 13, 2988.