205548 Caffeine - CAS 58-08-2 - Calbiochem

205548
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₀N₄O₂58-08-2

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205548-500GM
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      Glass bottle 500 gm
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      Description
      OverviewTrimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells.
      Catalogue Number205548
      Brand Family Calbiochem®
      Synonyms3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
      References
      ReferencesZhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
      Howell, L. L. 1993. Cancer Res. 54, 4993.
      Traganos, F., et al. 1993. Cancer Res. 53, 4613.
      Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.
      Product Information
      CAS number58-08-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₀N₄O₂
      Chemical formulaC₈H₁₀N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCaffeine, CAS 58-08-2, is a trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia.
      Biological Information
      Primary TargetPotent central nervous system stimulant
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEV6475000
      Safety Information
      R PhraseR: 22;

      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caffeine - CAS 58-08-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caffeine - CAS 58-08-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      205548

      References

      Reference overview
      Zhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
      Howell, L. L. 1993. Cancer Res. 54, 4993.
      Traganos, F., et al. 1993. Cancer Res. 53, 4613.
      Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Tools and Tips for Analyzing Apoptosis
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2018 JSW
      Synonyms3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
      DescriptionTrimethylated xanthine that acts as a potent central nervous system stimulant. A nonselective phosphodiesterase inhibitor. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin and topotecan in HL-60 cells.
      FormWhite solid
      CAS number58-08-2
      RTECSEV6475000
      Chemical formulaC₈H₁₀N₄O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityChloroform (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1636
      ReferencesZhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170.
      Howell, L. L. 1993. Cancer Res. 54, 4993.
      Traganos, F., et al. 1993. Cancer Res. 53, 4613.
      Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.