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215911 Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

Carbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCCP

Primary Target: cytochrome c oxydase
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215911
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Overview

Replacement Information

Key Spec Table

CAS #
555-60-2

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215911-250MG
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      		 Plastic ampoule 250 mg
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      Description
      OverviewProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
      Catalogue Number215911
      Brand Family Calbiochem®
      SynonymsCCCP
      References
      ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
      Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
      Product Information
      CAS number555-60-2
      ATP CompetitiveN
      FormYellow solid
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.
      Biological Information
      Primary Targetcytochrome c oxydase
      Primary Target IC<sub>50</sub>Kd = 270 nM in binding with cytochrome c oxidase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSFG5600000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      215911-250MG 04055977219241

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      215911

      References

      Reference overview
      Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
      Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCCCP
      DescriptionProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. ~100 times more effective than 2,4-dinitrophenol. Binds cytochrome C oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
      FormYellow solid
      CAS number555-60-2
      RTECSFG5600000
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Etthanol (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Toxicity Harmful
      ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
      Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.