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400006 Caspase-1/Caspase-4 Substrate II, Fluorogenic

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-WVAD-AMC

400006
  
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      Overview

      Replacement Information
      Description
      OverviewA fluorogenic substrate for caspase-1 (kcat/Km = 2.41 x 105 M-1s-1) and caspase-4. Exhibits ~2 fold higher affinity towards caspase-1 than for caspase-4.
      Catalogue Number400006
      Brand Family Calbiochem®
      SynonymsAc-WVAD-AMC
      References
      ReferencesLee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.
      Product Information
      FormLyophilized
      Hill FormulaC₃₅H₄₀N₆O₉
      Chemical formulaC₃₅H₄₀N₆O₉
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Emission max.
      Excitation max.
      Peptide SequenceAc-Trp-Val-Ala-Asp-AMC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      400006 0

      Documentation

      References

      Reference overview
      Lee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsAc-WVAD-AMC
      DescriptionA fluorogenic substrate for caspase-1 (kcat/Km = 241 mM-1s-1) and caspase-4. Exhibits ~2-fold higher affinity for caspase-1 than caspase-4 and displays ~4-fold greater sensitivity than Ac-YVAD-AMC (Cat. No. 400020) for measuring caspase-1 activity. Excitation max: ~360-380 nm; emission max: ~430-460 nm.
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₄₀N₆O₉
      Peptide SequenceAc-Trp-Val-Ala-Asp-AMC
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.