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218826 Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem

The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin

Primary Target: caspase-3
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      220509-74-0C₁₄H₁₆N₂O₅S
      Description
      OverviewA potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
      Catalogue Number218826
      Brand Family Calbiochem®
      Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
      References
      ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
      Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.
      Product Information
      CAS number220509-74-0
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₄H₁₆N₂O₅S
      Chemical formulaC₁₄H₁₆N₂O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-3
      Primary Target K<sub>i</sub> 60 nM, 170 nM, against caspase-3 and caspase-7, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218826 0

      Documentation

      Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      218826

      References

      Reference overview
      Lee, D., et al. 2001. J. Med. Chem. 44, 2015.
      Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-February-2014 JSW
      Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
      DescriptionA potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Inhibits caspase-9 to a lesser extent (Ki(app) = 3.1 µM). Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. Reported to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220509-74-0
      Chemical formulaC₁₄H₁₆N₂O₅S
      Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
      Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.