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219012 Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate

Primary Target: capase-3
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      745046-84-8C₂₀H₂₁N₃O₇S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
      Catalogue Number219012
      Brand Family Calbiochem®
      Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
      References
      ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.
      Product Information
      CAS number745046-84-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₂₁N₃O₇S
      Chemical formulaC₂₀H₂₁N₃O₇S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcapase-3
      Primary Target IC<sub>50</sub>23 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219012 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      219012

      References

      Reference overview
      Kravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
      DescriptionA cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number745046-84-8
      Chemical formulaC₂₀H₂₁N₃O₇S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.