218825 Caspase Inhibitor Set IV - Calbiochem

218825
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218825-1SET
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      Description
      OverviewA set of four ready-to-use cell-permeable, irreversible inhibitors of various caspase-family proteases and a negative control apoptosis inducer. Each vial contains 25 µl of a 10 mM solution in DMSO of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No 218761); general caspase inhibitor, Z-VAD-FMK (Cat. No. 627610); the negative control Z-FA-FMK (Cat. No. 342000), and an aqueous solution (100 µl, 6.1 µg/µl) of an apoptosis inducer, Doxorubicin, Hydrochloride (Cat. No. 324380). Supplied with a data sheet.
      Catalogue Number218825
      Brand Family Calbiochem®
      References
      Product Information
      ATP CompetitiveN
      FormLiquid
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetpan-caspase
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38-45-46

      Irritating to eyes and skin.
      May cause cancer.
      May cause heritable genetic damage.
      S PhraseS: 26-36/37-45-53-23-28

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Do not breathe fumes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase Inhibitor Set IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase Inhibitor Set IV - Calbiochem Certificates of Analysis

      TitleLot Number
      218825

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2010 RFH
      DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

      Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
      FormLiquid
      Intert gas (Yes/No) Packaged under inert gas
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Toxicity Multiple Toxicity Values, refer to MSDS