219402 Cathepsin L, Human Liver

219402
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Overview

Replacement Information

Key Spec Table

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219402-25UG
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      Glass bottle 25 μg
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      Description
      OverviewNative cathepsin L from human liver. The most potent of the lysosomal proteinases, having a higher activity than cathepsins B and H in the degradation of a variety of physiological protein substrates. Cathepsin L is believed to be responsible for the generation of endostatin from NC1 domain in collagen XVII.
      Note: 1 mU = 1 milliunit.
      Catalogue Number219402
      Brand Family Calbiochem®
      References
      ReferencesKurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
      Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
      Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
      McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5.
      EC number3.4.22.15
      FormLiquid
      FormulationIn 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5.
      Quality LevelMQ100
      Applications
      Biological Information
      SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin L, Human Liver SDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin L, Human Liver Certificates of Analysis

      TitleLot Number
      219402

      References

      Reference overview
      Kurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
      Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
      Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
      McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.

      Brochure

      Title
      Cathepsins and Related Products Technical Bulletin

      Citations

      Title
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionNative cathepsin L from human liver. The most powerful of the lysosomal proteinases, having a higher specific activity than cathepsins B and H in the degradation of a variety of physiological protein substances.
      FormLiquid
      FormulationIn 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      EC number3.4.22.15
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      Merck USA index14, 1905
      ReferencesKurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
      Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
      Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
      McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.
      Citation
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.