219494 Sigma-AldrichCdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem
The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<Synonyms: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(3-(2-pyridyl)phenylamino)-9-isopropylpurine, hydrate
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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1186647-87-9 | C₂₃H₂₇N₇O • H₂O |
Description | |
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Overview | A cell-permeable ATP-binding pocket-targeting (R)-Roscovitine (Cat. Nos. 550360 & 550364) derivative that is more potent than Roscovitine in inhibiting CDK1,CDK5, and CK1 activity (IC50 = 220,80,14 vs. 350, 200, 2300 nM, respectively), while maintaining selectivity against GSK-3α/β (IC50 = 4.1 µM). The CDK/CK1 dual-specificity nature of (R)-DRF053 most likely accounts for its superior activity to that of (R)-Roscovitine against β40 production from APP-expressing N2A cells (90% vs. 50% inhibition wtih 100 µM respective compound). |
Catalogue Number | 219494 |
Brand Family | Calbiochem® |
Synonyms | 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(3-(2-pyridyl)phenylamino)-9-isopropylpurine, hydrate |
References | |
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References | Oumata, N., et al. J. Med. Chem. 51, 5229. Bettayeb, K., et al. 2008. Oncogene 27, 5797. |
Product Information | |
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CAS number | 1186647-87-9 |
Form | Pale yellow solid |
Hill Formula | C₂₃H₂₇N₇O • H₂O |
Chemical formula | C₂₃H₂₇N₇O • H₂O |
Structure formula Image | |
Quality Level | MQ100 |
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Biological Information | |
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Purity | ≥95% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
219494 | 0 |
Documentation
Required Licenses
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PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD |
Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem SDS
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Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
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219494 |
References
Reference overview |
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Oumata, N., et al. J. Med. Chem. 51, 5229. Bettayeb, K., et al. 2008. Oncogene 27, 5797. |